This segment focuses on developing and marketing innovative therapies for neurovascular diseases, including stroke and aneurysms. Penumbra's neurovascular portfolio includes aspiration-based thrombectomy systems like the Penumbra System, embolization coiling systems such as Penumbra Coil 400, and neurovascular access systems like Neuron. Research and development efforts are directed towards improving the efficacy and safety of these devices, with a focus on enhancing clot retrieval rates and minimizing complications. The company also invests in clinical trials to validate the performance of its neurovascular products and expand their indications. These technologies aim to improve patient outcomes by enabling faster and more complete recanalization of occluded vessels, reducing the risk of long-term disability and death.

Penumbra's peripheral vascular segment is dedicated to providing solutions for peripheral artery disease (PAD) and venous thromboembolism (VTE). Key products include the Indigo System for aspiration thrombectomy in peripheral vessels and the Ruby Coil system for peripheral embolization. The company is actively involved in research and development to refine these technologies, focusing on improving device deliverability, clot removal efficiency, and long-term patency rates. Clinical studies are conducted to evaluate the safety and effectiveness of Penumbra's peripheral vascular devices in various patient populations. By offering minimally invasive treatment options, Penumbra aims to reduce the need for surgical interventions and improve the quality of life for patients with PAD and VTE.

This segment is focused on developing immersive computer-based technologies and immersive therapeutics to promote health, motor function, and cognition under the Real Immersive System brand. Penumbra is collaborating with the Veterans Health Administration to expand access to rehabilitative care using virtual reality. Research and development efforts are directed towards creating engaging and effective VR-based therapies for various neurological and physical conditions. Clinical trials are conducted to assess the impact of these immersive technologies on patient outcomes, with a focus on improving motor skills, cognitive function, and overall well-being. By leveraging the power of virtual reality, Penumbra aims to provide innovative and accessible rehabilitation solutions for patients in both clinical and home settings.