This segment focuses on developing and commercializing advanced filtration solutions for upstream and downstream bioprocessing. Key technologies include Alternating Tangential Flow (ATF) systems, TangenX flat sheet cassettes, and KrosFlo tangential flow filtration systems. R&D efforts are directed towards improving cell culture processing, biologic drug concentration, and formulation processes. These technologies are crucial for enhancing product yield, purity, and process efficiency in biopharmaceutical manufacturing. The filtration segment addresses the critical need for scalable and reliable solutions in biologics production, impacting patient outcomes by ensuring the availability of high-quality therapeutics. Future opportunities include expanding into new applications such as gene therapy and vaccine manufacturing, leveraging partnerships to integrate filtration solutions with other bioprocessing platforms.

This segment specializes in chromatography products, including OPUS pre-packed columns and chromatography resins under the CaptivA brand. These products are essential for the purification of biologics, high-throughput process development screening, and viral clearance validation studies. Research and development efforts are focused on creating novel affinity ligands and resins with improved binding capacity and selectivity. The chromatography solutions segment plays a vital role in ensuring the purity and safety of biopharmaceutical products, directly impacting patient health. By offering scalable and efficient purification solutions, Repligen enables manufacturers to streamline their processes and reduce costs. Future growth potential lies in developing specialized resins for emerging therapeutic modalities and expanding the OPUS column portfolio to meet diverse customer needs.

This segment provides advanced process analytics products, such as slope spectroscopy systems under the SoloVPE, FlowVPE, and FlowVPX brands. These systems enable real-time monitoring and control of critical process parameters, enhancing process understanding and optimization. R&D activities are centered on developing innovative analytical tools for bioprocessing, including sensors, software, and data analytics platforms. The process analytics segment contributes to improved product quality, process consistency, and regulatory compliance in biopharmaceutical manufacturing. By providing real-time insights into process performance, these tools empower manufacturers to make data-driven decisions and optimize their operations. Future opportunities include integrating process analytics with automation and control systems, enabling closed-loop manufacturing and continuous process improvement.