This segment focuses on providing tools and solutions for Next-Generation Sequencing (NGS) workflows. Twist Bioscience offers a comprehensive portfolio of NGS products, including target enrichment panels, custom panels, and library preparation kits. Research and development efforts are focused on improving the efficiency, accuracy, and throughput of NGS workflows. Technologies used include silicon-based DNA synthesis for creating high-quality probes and adapters. These tools are used in various therapeutic areas, including oncology, infectious diseases, and genetic testing, enabling researchers to analyze DNA and RNA for disease diagnosis, treatment selection, and drug discovery. The impact is improved diagnostic accuracy, personalized medicine, and accelerated research. Twist's market positioning is strong due to its innovative silicon-based platform and ability to provide custom solutions. Future opportunities include expanding into new NGS applications and developing integrated solutions. Partnerships with companies like Element Biosciences are key to expanding market reach. Regulatory and clinical aspects are important for diagnostic applications.

This segment focuses on the discovery and development of novel antibodies for therapeutic applications. Twist Bioscience leverages its synthetic DNA platform to create diverse antibody libraries, enabling the identification of antibodies against various disease targets. Research and development activities include the design and synthesis of antibody libraries, screening for high-affinity antibodies, and optimization of antibody candidates. Technologies used include high-throughput screening, next-generation sequencing, and bioinformatics. Therapeutic areas covered include oncology, immunology, and infectious diseases. The patient impact is the development of new and more effective treatments for diseases. Twist Bioscience's market positioning is enhanced by its ability to rapidly generate diverse antibody libraries and its collaborations with pharmaceutical companies. Future opportunities include expanding into new therapeutic areas and developing bispecific antibodies. Partnerships with companies like Bayer and Absci are crucial for advancing antibody discovery programs. Regulatory and clinical aspects are important for the development and approval of therapeutic antibodies.

This segment focuses on the production and sale of synthetic genes and oligo pools for a wide range of applications. Twist Bioscience uses its silicon-based platform to synthesize DNA at scale, providing customers with high-quality, custom-designed genes and oligo pools. Research and development efforts are focused on improving synthesis efficiency, accuracy, and throughput. Technologies used include DNA synthesis on silicon chips, automated manufacturing, and quality control. Applications include gene synthesis, CRISPR-Cas9 gene editing, and synthetic biology research. The patient impact is indirect, as these products enable advancements in drug discovery, diagnostics, and basic research. Twist Bioscience's market positioning is strong due to its ability to provide high-quality, custom DNA products at competitive prices. Future opportunities include expanding into new applications, such as DNA data storage and personalized medicine. Regulatory and clinical aspects are relevant for applications in diagnostics and therapeutics.