This segment focuses on the core mission of developing technologies and processes to enable the transplantation of cells, tissues, and organs from non-human species (primarily swine) into humans. Research efforts are directed towards overcoming immunological barriers and preventing rejection of xenografts. Key activities include genetic modification of donor animals to reduce immunogenicity, development of immunosuppressive therapies, and preclinical studies to assess the safety and efficacy of xenotransplantation. The ultimate goal is to provide a viable solution to the critical shortage of human organs available for transplantation, improving patient survival and quality of life. Future opportunities include expanding the range of transplantable tissues and organs, refining immunosuppression protocols, and advancing clinical trials to demonstrate the long-term benefits of xenotransplantation.