Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Makena, Proluton Depot
17-Hydroxyprogesterone is a naturally occurring progestogen hormone produced in the adrenal glands and gonads. It is a precursor to cortisol and other steroid hormones. Synthetic versions of 17-hydroxyprogesterone, such as 17-hydroxyprogesterone caproate (17-OHPC), are used as medications, primarily to prevent preterm birth in women at high risk.
Used to prevent preterm birth in women with a history of preterm delivery or a short cervix.
Outcome:
Reduced efficacy of 17-OHP
Mechanism:
Induction of hepatic enzymes
Outcome:
Increased risk of bleeding
Mechanism:
Additive antiplatelet effects
Outcome:
No clinically significant interaction expected
Mechanism:
Different metabolic pathways
Most likely new formulation: sustained-release implant (Year 2026, 60% confidence)
Based on current usage patterns and clinical trial data, there is a 70% likelihood of 17-OHP remaining a first-line treatment for preventing preterm birth in the next 5 years.
Progestogen, Steroid Hormone
Steroid