Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Adrucil, Efudex, Carac, FluoroPlex
5-Fluorouracil (5-FU) is an antimetabolite chemotherapy drug used to treat various types of cancer. It belongs to the pyrimidine analog class and works by interfering with DNA and RNA synthesis, ultimately inhibiting cell growth and division. It is commonly used in combination with other chemotherapy agents.
For the treatment of various cancers, including colorectal, breast, esophageal, stomach, pancreatic, and head and neck cancers.
Severe or fatal toxicity, including mucositis, diarrhea, myelosuppression, and cardiotoxicity, can occur. Patients should be closely monitored.
Outcome:
Increased bleeding risk
Mechanism:
Altered metabolism
Outcome:
Increased 5-FU toxicity
Mechanism:
Reduced 5-FU metabolism
Outcome:
Reduced 5-FU absorption
Mechanism:
Altered gastrointestinal pH
Most likely new formulation: Liposomal or nanoparticle delivery systems to improve efficacy and reduce toxicity (2025-2030, 70% confidence)
Based on historical usage and clinical trial data, 5-FU has a high likelihood of remaining a standard of care in cancer treatment for the foreseeable future.
Antineoplastic, Antimetabolite, Pyrimidine Analog
Pyrimidine