Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Sectral
Acebutolol is a beta-blocker medication primarily used to treat high blood pressure and abnormal heart rhythms. It belongs to the class of cardioselective beta-blockers, meaning it preferentially blocks beta-1 receptors in the heart, minimizing effects on beta-2 receptors in the lungs. This selectivity makes it generally safer for patients with asthma or chronic obstructive pulmonary disease (COPD) compared to non-selective beta-blockers. Acebutolol works by reducing heart rate and the force of heart contractions, lowering blood pressure and stabilizing heart rhythms. It also possesses some intrinsic sympathomimetic activity (ISA), meaning it can mildly stimulate the heart at low doses, potentially leading to a smaller decrease in resting heart rate compared to other beta-blockers.
For treating high blood pressure and abnormal heart rhythms.
Outcome:
Increased risk of bradycardia
Mechanism:
Additive effects on heart rate
Outcome:
Reduced antihypertensive effect
Mechanism:
NSAIDs can inhibit prostaglandin synthesis, which can reduce the effectiveness of beta-blockers.
Outcome:
Slight reduction in antihypertensive effect
Mechanism:
Caffeine can stimulate the cardiovascular system.
Most likely new formulation: Extended-release formulation for improved patient compliance (Year: 2026, 30% confidence)
Based on current usage trends and clinical trial data, there is a low probability ( <5%) of any significant regulatory changes for acebutolol in the next 2 years.
Beta-blocker, Cardioselective beta-blocker
Aryloxypropanolamine