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Brand: Adenocard, Adenoscan
Adenosine is a naturally occurring purine nucleoside that plays a crucial role in various physiological processes, including energy transfer, signal transduction, and vasodilation. It acts as an endogenous antiarrhythmic agent, primarily by slowing conduction time through the atrioventricular (AV) node. Adenosine is classified as a nucleoside and is used clinically for the diagnosis and treatment of certain types of supraventricular tachycardia (SVT).
For the conversion of paroxysmal supraventricular tachycardia (PSVT) to sinus rhythm and for diagnostic purposes in cardiac stress testing.
Outcome:
Increased risk of adenosine side effects (e.g., bradycardia, hypotension, bronchospasm).
Mechanism:
Dipyridamole inhibits adenosine uptake and metabolism, potentiating its effects.
Outcome:
May enhance AV nodal blocking effects.
Mechanism:
Additive effects on AV node conduction.
Outcome:
May decrease the effectiveness of adenosine.
Mechanism:
Atropine increases heart rate and counteracts adenosine's slowing effect.
Most likely new formulation: extended-release oral formulation for chronic SVT management (Year: 2028, 30% confidence)
Based on current usage trends and clinical trial activity, there is a low ( <5%) likelihood of any significant regulatory changes for adenosine in the next 2 years.
Antiarrhythmic, Nucleoside
Purine Nucleoside