Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Valdoxan, Thymanax
Agomelatine is an antidepressant medication primarily used to treat major depressive disorder (MDD) in adults. It is classified as a melatonergic agonist and 5-HT2C receptor antagonist. Agomelatine works by resynchronizing circadian rhythms and modulating serotonin levels in the brain, which are often disrupted in individuals with depression.
For the treatment of major depressive episodes in adults.
Outcome:
Increased agomelatine levels
Mechanism:
CYP1A2 inhibition
Outcome:
Altered agomelatine metabolism
Mechanism:
CYP2C19 inhibition
Outcome:
No clinically significant interaction
Mechanism:
Different metabolic pathways
Most likely new formulation: Extended-release formulation (2026, 30% confidence)
Based on current usage trends and clinical trial data, there is a low probability of FDA approval in the next 5 years.
Antidepressant, Melatonergic Agonist, 5-HT2C Receptor Antagonist
Naphthalenesulfonamide