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Discover all available medicines and treatments
Brand: Demser
Alpha-Methyl-p-tyrosine (AMPT), also known as metirosine, is an antihypertensive drug that works by inhibiting the enzyme tyrosine hydroxylase, which is crucial in the biosynthesis of catecholamines like dopamine, norepinephrine, and epinephrine. This inhibition reduces the production of these neurotransmitters, making it useful in managing conditions with excessive catecholamine levels, such as pheochromocytoma.
Used to control blood pressure and other symptoms caused by excessive catecholamines, primarily in pheochromocytoma.
Outcome:
Severe hypotension
Mechanism:
Additive reduction of catecholamine synthesis and metabolism.
Outcome:
Potential for extrapyramidal symptoms
Mechanism:
Dopamine depletion can exacerbate extrapyramidal effects.
Outcome:
Reduced effectiveness of AMPT
Mechanism:
Caffeine can counteract the catecholamine-lowering effects of AMPT.
Most likely new formulation: Extended-release AMPT (Year: 2027, 30% confidence)
Based on current usage patterns and clinical trial data, there is a low (<5%) likelihood of regulatory changes to AMPT's approved indications in the next 5 years.
Antihypertensive, Tyrosine Hydroxylase Inhibitor
Tyrosine analog