Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Midamor, Moduretic
Amiloride is a potassium-sparing diuretic that is primarily used to treat fluid retention (edema) and high blood pressure (hypertension). It belongs to the class of pyrazinoylguanidine diuretics and works by blocking sodium channels in the distal tubules of the kidneys, which leads to increased excretion of sodium and water while minimizing the loss of potassium. It is often used in combination with other diuretics like thiazides to enhance their effects and reduce the risk of potassium depletion.
For treating fluid retention (edema) and high blood pressure (hypertension), often in combination with other diuretics.
Outcome:
Increased risk of hyperkalemia
Mechanism:
Both drugs can increase potassium levels.
Outcome:
Increased digoxin toxicity
Mechanism:
Amiloride can increase potassium levels, potentiating digoxin's effects.
Outcome:
Increased risk of kidney damage
Mechanism:
Additive nephrotoxic effects.
Most likely new formulation: Extended-release amiloride (Year: 2026, 70% confidence)
Based on current usage trends and safety profile, amiloride has a low probability (<1%) of being withdrawn from the market in the next 5 years.
Potassium-Sparing Diuretic, Pyrazinoylguanidine
Pyrazinoylguanidine