Medicines
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Discover all available medicines and treatments
Brand: Amytal, Amytal Sodium
Amobarbital is a barbiturate, a class of drugs that act as central nervous system depressants. It enhances the effect of the neurotransmitter GABA, leading to decreased neuronal activity. Historically used as a sedative and hypnotic, its use has declined due to safety concerns and the availability of safer alternatives. It is still occasionally used for short-term treatment of insomnia, as an anticonvulsant, and as a pre-operative sedative.
Short-term treatment of insomnia, pre-operative sedation, and as an anticonvulsant.
Barbiturates carry a risk of dependence and abuse. Abrupt withdrawal can cause severe withdrawal symptoms, including seizures. Respiratory depression and overdose can be fatal.
Outcome:
Increased CNS depression, respiratory depression, possible death
Mechanism:
Additive CNS depressant effects
Outcome:
Decreased effectiveness of warfarin
Mechanism:
Induction of hepatic enzymes
Outcome:
Mild increased sedation
Mechanism:
Additive CNS depressant effects
Most likely new formulation: Extended-release formulation for specific indications (Year: 2026, 30% confidence)
Based on the declining usage trends and safety concerns, the likelihood of further restrictions on amobarbital use is 70% within the next 5 years.
Barbiturate, Hypnotic, Sedative, Anticonvulsant
Barbiturate