Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Fungizone, Ambisome, Abelcet, Amphotec, Amphocin
Amphotericin B is a potent antifungal medication used to treat serious, life-threatening fungal infections. It belongs to the polyene class of antifungals and works by binding to ergosterol, a component of fungal cell membranes, leading to cell death. It is available in various formulations, including conventional amphotericin B deoxycholate, lipid-based formulations, and a liposomal formulation.
For the treatment of serious, potentially life-threatening systemic fungal infections.
Outcome:
Increased risk of kidney damage
Mechanism:
Additive nephrotoxicity
Outcome:
Increased risk of hypokalemia
Mechanism:
Additive effects on potassium excretion
Outcome:
May mask allergic reactions to amphotericin B
Mechanism:
Suppression of allergic symptoms
Most likely new formulation: improved lipid-based formulations with reduced toxicity (2025, 80% confidence)
Based on current usage trends and emerging resistance patterns, there is a 70% likelihood of new guidelines for amphotericin B use within the next 5 years.
Antifungal, Polyene
Polyene Macrolide