Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Adriamycin, Doxil, Ellence, Rubidomycin, Pharmorubicin
Anthracyclines are a class of chemotherapy drugs used to treat a variety of cancers. They work by interfering with DNA and RNA synthesis, which prevents cancer cells from growing and dividing. Anthracyclines are broad-spectrum antitumor antibiotics and are considered cytotoxic agents.
Used to treat a variety of cancers, including leukemia, lymphoma, breast cancer, stomach cancer, uterine cancer, ovarian cancer, bladder cancer, and lung cancer.
Anthracyclines can cause heart damage (cardiomyopathy) that can lead to congestive heart failure. The risk of heart damage is related to the total cumulative dose received over a lifetime. Careful monitoring of heart function is necessary during treatment.
Outcome:
Increased risk of cardiotoxicity
Mechanism:
Synergistic cardiotoxic effects
Outcome:
May increase anthracycline levels
Mechanism:
Inhibition of metabolism
Outcome:
May decrease anthracycline absorption
Mechanism:
Chelation/binding
Most likely new formulation: Liposomal encapsulation or antibody-drug conjugates (2026, 80% confidence)
Based on ongoing research and clinical trial data, there is a 70% likelihood of new anthracycline formulations with reduced cardiotoxicity being approved within the next 5 years.
Antineoplastic, Antibiotic, Cytotoxic
Anthracycline