Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Apokyn, Ixense, Spontane, Uprima
Apomorphine is a dopamine agonist primarily used in the treatment of Parkinson's disease, specifically for managing motor fluctuations (off episodes). It acts directly on dopamine receptors in the brain, mimicking the effects of dopamine and helping to alleviate the symptoms associated with dopamine deficiency. It can be administered subcutaneously or via an oral dissolving film.
For treating motor fluctuations (off episodes) in Parkinson's disease.
May cause severe hypotension and loss of consciousness, particularly with first dose; administer in setting where blood pressure monitoring is available. May cause nausea and vomiting; pre-treat with trimethobenzamide for at least 2 days prior to initiation.
Outcome:
Severe hypotension
Mechanism:
Additive vasodilatory effects
Outcome:
Increased sedation and risk of hypotension
Mechanism:
Additive CNS depressant effects
Outcome:
Reduced absorption of apomorphine
Mechanism:
Chelation or altered gastric pH
Most likely new formulation: Continuous subcutaneous infusion system (2025, 60% confidence)
Based on current usage trends and clinical trial data, there is a 75% likelihood of Apomorphine maintaining its approved status for Parkinson's disease treatment in the next 5 years.
Dopamine agonist, Antiparkinson agent
Morphinan