Medicines
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Discover all available medicines and treatments
Brand: Imuran, Azasan
Azathioprine is an immunosuppressant drug primarily used to prevent organ rejection after transplantation and to treat autoimmune conditions. It belongs to the class of purine antimetabolites and works by interfering with the synthesis of DNA and RNA, thereby suppressing the immune system's activity. This helps to prevent the body from attacking transplanted organs or its own tissues in autoimmune diseases.
Used to prevent organ rejection after transplantation and to treat autoimmune conditions like rheumatoid arthritis, Crohn's disease, and lupus.
Increased risk of malignancy, especially lymphoproliferative disorders and skin cancers; increased risk of infections, including opportunistic infections; bone marrow suppression; hepatotoxicity.
Outcome:
Increased risk of azathioprine toxicity (myelosuppression)
Mechanism:
Allopurinol inhibits xanthine oxidase, which is involved in azathioprine metabolism.
Outcome:
Increased risk of gastrointestinal bleeding and ulceration
Mechanism:
Additive effects on gastrointestinal mucosa.
Outcome:
Increased risk of liver damage
Mechanism:
Both alcohol and azathioprine are metabolized by the liver.
Most likely new formulation: Extended-release formulation to improve patient compliance (2025, 60% confidence)
Based on current usage trends and emerging therapies, there is a 70% likelihood of azathioprine maintaining its current FDA approval status for the next 5 years.
Immunosuppressant, Antimetabolite, Purine Analog
Purine Analog