Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Lotensin
Benazeprilat is the active metabolite of benazepril, an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action leads to vasodilation, reduced blood volume, and decreased aldosterone secretion, ultimately lowering blood pressure and improving cardiac function in certain conditions like heart failure.
Used to treat hypertension and heart failure.
Fetal toxicity: Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potentially other adverse effects include fetal skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue benazepril as soon as possible.
Outcome:
Hyperkalemia
Mechanism:
Reduced potassium excretion
Outcome:
Hypotension
Mechanism:
Additive hypotensive effects
Outcome:
Slightly decreased absorption
Mechanism:
Delayed gastric emptying
Most likely new formulation: Combination therapy with a thiazide diuretic (Year: 2025, 30% confidence)
Based on current usage trends and clinical trial data, there is a low ( <5%) likelihood of any major regulatory changes in the next 2 years.
ACE Inhibitor, Antihypertensive
Dicarboxylate-containing non-thiol ACE inhibitor