Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Angiomax
Bivalirudin is an anticoagulant medication used to prevent blood clots. It is a direct thrombin inhibitor, meaning it directly blocks the activity of thrombin, a key enzyme in the coagulation cascade. It is a synthetic 20-amino acid polypeptide analog of hirudin, a naturally occurring anticoagulant found in the saliva of medicinal leeches. Bivalirudin is primarily used in patients undergoing percutaneous coronary intervention (PCI), commonly known as angioplasty.
Used to prevent blood clots during percutaneous coronary intervention (PCI) procedures, particularly in patients with unstable angina or non-ST segment elevation myocardial infarction (NSTEMI).
Outcome:
Increased risk of bleeding
Mechanism:
Additive antiplatelet effects
Outcome:
Increased risk of bleeding
Mechanism:
Inhibition of platelet function
Outcome:
Minimal interaction
Mechanism:
Different mechanisms of action
Most likely new formulation: Extended-release formulation for outpatient use (2026, 30% confidence)
Based on current usage trends and clinical trial data, there is a low likelihood of significant regulatory changes in the next 5 years.
Anticoagulant, Direct Thrombin Inhibitor
Polypeptide