Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Alphagan, Alphagan P, Brimonidine Tartrate Ophthalmic Solution 0.15%, Mirvaso, Lumify
Brimonidine is an alpha-2 adrenergic agonist primarily used to lower intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It works by reducing the production of aqueous humor and increasing uveoscleral outflow. It is available as both a topical ophthalmic solution and an oral formulation, though the oral form is less commonly used due to systemic side effects.
For lowering intraocular pressure in open-angle glaucoma or ocular hypertension.
Outcome:
Increased risk of hypotension and bradycardia
Mechanism:
Additive alpha-2 adrenergic agonist effects
Outcome:
Increased drowsiness
Mechanism:
Additive sedative effects
Outcome:
Potential antagonism of brimonidine's ocular hypotensive effect
Mechanism:
Caffeine's vasoconstrictive properties
Most likely new formulation: sustained-release implant (Year: 2026, 60% confidence)
Based on current usage trends and ongoing clinical trials, there is a 70% likelihood of expanded indications for brimonidine in the next 5 years.
Alpha-2 adrenergic agonist, Antiglaucoma agent
Oxazolidine