Medicines
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Discover all available medicines and treatments
Brand: Bumex, Burinex
Bumetanide is a potent loop diuretic used to treat edema (fluid retention) associated with heart failure, liver disease, and kidney disease. It belongs to the class of medications known as loop diuretics, which work by inhibiting the reabsorption of sodium and chloride in the loop of Henle in the kidneys. This leads to increased excretion of water and electrolytes, reducing fluid buildup in the body.
For treating edema (fluid retention) associated with heart failure, liver disease, and kidney disease.
Outcome:
Increased risk of ototoxicity (hearing loss)
Mechanism:
Additive effects on inner ear function
Outcome:
Hypokalemia
Mechanism:
Additive effects on potassium excretion
Outcome:
Reduced bumetanide absorption
Mechanism:
Binding of bumetanide in the GI tract
Most likely new formulation: sustained-release formulation (Year 2026, 70% confidence)
Based on current usage trends and clinical trial data, there is a low (5%) likelihood of any major regulatory changes in the next 2 years.
Loop Diuretic
Sulfamylbenzoic acid derivative