Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Wellbutrin, Zyban, Aplenzin, Forfivo XL
Bupropion is an antidepressant medication primarily used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). It is also used as a smoking cessation aid. Bupropion belongs to the class of aminoketones and is chemically unrelated to other antidepressant classes like tricyclics, SSRIs, or MAOIs. It is believed to work by affecting the balance of neurotransmitters, specifically dopamine and norepinephrine, in the brain. Bupropion's unique mechanism of action often makes it suitable for individuals who do not respond well to other antidepressants or experience undesirable side effects like weight gain or sexual dysfunction.
For major depressive disorder, seasonal affective disorder, and smoking cessation.
Bupropion carries a black box warning regarding an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults.
Outcome:
Hypertensive crisis
Mechanism:
Increased catecholamine levels
Outcome:
Altered blood pressure
Mechanism:
Additive effects on the cardiovascular system
Outcome:
Potential for increased QT interval prolongation
Mechanism:
Additive effects on cardiac conduction
Most likely new formulation: Extended-release combination therapy with a second-generation antipsychotic (Year: 2026, 60% confidence)
Based on current usage trends and clinical trial data, there is a 70% likelihood of bupropion remaining a first-line treatment for depression and smoking cessation.
Aminoketone Antidepressant, Smoking Cessation Aid
Aminoketone