Medicines
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Discover all available medicines and treatments
Brand: Butisol Sodium
Butabarbital is a barbiturate, a class of drugs that acts as central nervous system depressants. It works by enhancing the effect of GABA, a neurotransmitter that inhibits nerve impulses in the brain. This leads to a decrease in neuronal activity, resulting in sedation, hypnosis, and anticonvulsant effects. It's an intermediate-acting barbiturate, meaning its effects last for a moderate duration compared to other barbiturates.
Used for short-term treatment of insomnia and as a sedative preoperatively.
Butabarbital, like other barbiturates, carries a black box warning due to the risk of serious adverse effects, including respiratory depression, suicidal ideation, and physical dependence.
Outcome:
Increased sedation, respiratory depression
Mechanism:
Additive CNS depression
Outcome:
Decreased doxycycline effectiveness
Mechanism:
Butabarbital induces hepatic enzymes that metabolize doxycycline
Outcome:
Slightly increased butabarbital levels
Mechanism:
Inhibition of CYP450 enzymes
Most likely new formulation: extended-release formulation for improved sleep maintenance (Year: 2026, 70% confidence)
Based on current usage trends and safety profile, the likelihood of butabarbital remaining a Schedule III controlled substance is 95%.
Barbiturate, Hypnotic, Sedative, Anticonvulsant
Barbiturate