Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Capoten, Capozide
Captopril is an angiotensin-converting enzyme (ACE) inhibitor primarily used to treat hypertension (high blood pressure), heart failure, and diabetic kidney disease. It works by preventing the formation of angiotensin II, a hormone that narrows blood vessels and increases blood pressure. Captopril belongs to the class of sulfhydryl-containing ACE inhibitors.
For treating hypertension, heart failure, and diabetic kidney disease.
Fetal toxicity: Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death.
Outcome:
Increased risk of hypotension, hyperkalemia, and renal impairment.
Mechanism:
Synergistic effects on the renin-angiotensin system.
Outcome:
Increased risk of first-dose hypotension.
Mechanism:
Additive hypotensive effects.
Outcome:
Reduced absorption of captopril.
Mechanism:
Delayed gastric emptying.
Most likely new formulation: Extended-release formulation (Year: 2025, 70% confidence)
Based on usage patterns and clinical trial data, there is a low (<1%) likelihood of Captopril being withdrawn from the market in the next 5 years.
ACE Inhibitor, Antihypertensive
Sulfhydryl-containing ACE Inhibitor