Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Leukeran
Chlorambucil is an alkylating antineoplastic agent used to treat various types of cancer. It belongs to the nitrogen mustard class of drugs and works by interfering with DNA replication and cell division. This slows or stops the growth of cancer cells.
Used to treat chronic lymphocytic leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphoma, Waldenström macroglobulinemia, and other cancers.
Chlorambucil increases the risk of secondary malignancies, including myelodysplastic syndrome and acute myeloid leukemia.
Outcome:
Reduced vaccine efficacy, increased risk of infection
Mechanism:
Chlorambucil suppresses the immune system
Outcome:
Increased risk of bleeding
Mechanism:
Both drugs can affect platelet function
Outcome:
Reduced chlorambucil absorption
Mechanism:
Altered drug absorption
Most likely new formulation: Liposomal encapsulation for improved targeting and reduced toxicity (Year: 2026, 30% confidence)
Based on current usage trends and clinical trial activity, there is a low ( <5%) likelihood of a major regulatory change in the next 2 years.
Alkylating agent, Nitrogen mustard
Nitrogen Mustard