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Brand: Nesacaine, Nesacaine-MPF
Chloroprocaine is a short-acting local anesthetic used for infiltration anesthesia, peripheral nerve blocks, and epidural anesthesia. It belongs to the ester class of local anesthetics and works by blocking sodium channels, preventing nerve impulse transmission. Its rapid onset and short duration of action make it suitable for procedures requiring brief anesthesia.
For local anesthesia during surgical procedures, including infiltration, peripheral nerve blocks, and epidural anesthesia.
Outcome:
Reduced efficacy of chloroprocaine
Mechanism:
Competition for plasma protein binding
Outcome:
Increased risk of bleeding
Mechanism:
Inhibition of platelet function
Outcome:
Slightly reduced absorption of chloroprocaine
Mechanism:
Altered gastric pH
Most likely new formulation: Liposomal chloroprocaine for extended duration of action (2025, 70% confidence)
Based on current usage trends and safety profile, chloroprocaine is likely to maintain its FDA-approved status for local anesthesia.
Local Anesthetic, Ester
Ester Local Anesthetic