Medicines
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Discover all available medicines and treatments
Brand: Vistide
Cidofovir is an antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients with AIDS. It is a nucleotide analogue that inhibits viral DNA polymerase, thereby preventing viral replication. Cidofovir is administered intravenously and is typically used when other treatments have failed or are not tolerated.
For the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS.
Nephrotoxicity: Cidofovir can cause serious kidney damage. Patients should be prehydrated with intravenous fluids before each dose and receive probenecid with each infusion. Monitor renal function closely.
Outcome:
Increased risk of nephrotoxicity
Mechanism:
Reduced renal clearance of cidofovir
Outcome:
Increased risk of nephrotoxicity
Mechanism:
Reduced renal blood flow
Outcome:
Reduced absorption of cidofovir
Mechanism:
Chelation
Most likely new formulation: sustained-release implant for CMV retinitis (2026, 30% confidence)
Based on current usage trends and clinical trial data, there is a low likelihood of significant regulatory changes to cidofovir's approved indications in the next 5 years.
Antiviral
Acyclic Nucleoside Phosphonate