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Discover all available medicines and treatments
Brand: Sensipar, Mimpara
Cinacalcet is a calcimimetic drug used to treat secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on dialysis and hypercalcemia in patients with parathyroid carcinoma. It works by mimicking the action of calcium on the calcium-sensing receptor (CaSR) in the parathyroid gland, decreasing parathyroid hormone (PTH) secretion.
Used to treat secondary hyperparathyroidism in patients with chronic kidney disease on dialysis and hypercalcemia in patients with parathyroid carcinoma.
Outcome:
Increased cinacalcet levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Potential alteration in INR
Mechanism:
Unknown
Outcome:
Potential reduced absorption of cinacalcet
Mechanism:
Changes in gastric pH
Most likely new formulation: Extended-release formulation (2025, 70% confidence)
Based on increasing prevalence of CKD and SHPT, continued market growth for cinacalcet is expected (7% annual growth predicted).
Calcimimetic
Naphthalenyl Acetamide