Medicines
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Discover all available medicines and treatments
Brand: Cloderm, Cloderm Cream, Cloderm Ointment
Clocortolone pivalate is a synthetic corticosteroid used topically for the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It belongs to the class of glucocorticoids and functions by binding to glucocorticoid receptors in the skin, reducing inflammation, itching, and redness.
For the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Outcome:
Increased systemic absorption of clocortolone.
Mechanism:
CYP3A4 inhibition leads to reduced clocortolone metabolism.
Outcome:
Increased risk of gastrointestinal bleeding.
Mechanism:
Additive effects on gastric mucosa.
Outcome:
No clinically significant interactions expected.
Mechanism:
Topical application limits systemic absorption.
Most likely new formulation: Improved topical delivery systems for enhanced efficacy and reduced side effects (2025, 75% confidence).
Based on current usage trends and safety profile, clocortolone pivalate is expected to remain a viable treatment option for dermatological conditions with a low likelihood of regulatory changes in the near future (90% confidence).
Corticosteroid, Topical
Glucocorticoid