Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Lamprene
Clofazimine is a rminophenazine dye with antimycobacterial and anti-inflammatory properties. It is primarily used in combination therapy for the treatment of multidrug-resistant leprosy, particularly lepromatous leprosy. Its mechanism of action is complex and not fully understood, but it involves binding to bacterial DNA, inhibiting mycobacterial growth, and potentially modulating the immune response.
For the treatment of multidrug-resistant leprosy, particularly lepromatous leprosy.
Outcome:
Increased risk of torsades de pointes
Mechanism:
Additive QT prolongation
Outcome:
Increased risk of gastrointestinal side effects
Mechanism:
Additive irritant effect
Outcome:
No clinically significant interaction expected
Mechanism:
Unknown
Most likely new formulation: Liposomal clofazimine for improved bioavailability and reduced side effects (2025, 60% confidence)
Based on current usage trends and clinical trial data, there is a low likelihood of significant changes to the regulatory status of clofazimine in the next 5 years.
Anti-leprosy, Immunomodulator
Phenazine Dye