Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Tybost
Cobicistat is a pharmacoenhancer, specifically a CYP3A inhibitor, used to boost the blood levels of certain HIV medications. It works by inhibiting the enzyme CYP3A, which is responsible for metabolizing many drugs, including some HIV protease inhibitors and integrase inhibitors. By slowing down the metabolism of these HIV drugs, cobicistat increases their concentration in the body, allowing for lower doses and potentially fewer side effects.
Used as a pharmacoenhancer to increase the effectiveness of certain HIV medications.
Outcome:
Increased atazanavir levels, potential for toxicity.
Mechanism:
CYP3A inhibition
Outcome:
Increased amlodipine levels, potential for hypotension.
Mechanism:
CYP3A inhibition
Outcome:
Slightly increased caffeine levels.
Mechanism:
CYP3A inhibition
Most likely new formulation: Combination therapies with other HIV drugs (2024, 70% confidence)
Based on current usage trends and clinical trial data, cobicistat is expected to maintain its current regulatory status.
Pharmacokinetic Booster, CYP3A Inhibitor
Booster