Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Coly-Mycin, Colomycin, Colistinat
Colistin is an antibiotic belonging to the polymyxin class. It works by disrupting the bacterial cell membrane, leading to cell death. It's primarily used to treat infections caused by multidrug-resistant Gram-negative bacteria. Due to its potential for nephrotoxicity and neurotoxicity, colistin is often reserved as a last-resort treatment option when other antibiotics are ineffective.
Used to treat serious infections caused by multidrug-resistant Gram-negative bacteria.
Nephrotoxicity and neurotoxicity are potential serious side effects of colistin.
Outcome:
Increased neuromuscular blockade
Mechanism:
Additive neuromuscular blockade
Outcome:
Increased nephrotoxicity
Mechanism:
Reduced renal blood flow
Outcome:
Decreased absorption of colistin
Mechanism:
Chelation or binding
Most likely new formulation: inhaled colistin for lung infections (2025, 60% confidence)
Based on increasing resistance patterns, there is a 70% likelihood of expanded indications for colistin in the next 5 years.
Antibiotic, Polymyxin
Polymyxin