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Discover all available medicines and treatments
Brand: Cuprimine, Depen
D-penicillamine is a chelating agent, primarily used to remove excess copper from the body in Wilson's disease. It also finds application in treating rheumatoid arthritis, cystinuria, and scleroderma. It acts by binding to copper and other heavy metals, facilitating their excretion in the urine. Its use requires careful monitoring due to potential serious side effects.
Used for Wilson's disease, rheumatoid arthritis, cystinuria, and scleroderma.
D-penicillamine can cause serious hematologic, renal, and dermatologic adverse reactions. Blood counts and urinalysis should be closely monitored.
Outcome:
Increased risk of blood disorders and kidney damage
Mechanism:
Additive toxicity
Outcome:
Increased risk of gastrointestinal bleeding
Mechanism:
Additive effect on gastric mucosa
Outcome:
Reduced absorption of D-penicillamine
Mechanism:
Chelation with food components
Most likely new formulation: sustained-release formulation (2026, 30% confidence)
Based on current usage trends and safety profile, there is a low (5%) likelihood of regulatory changes for D-penicillamine in the next 5 years.
Chelating agent, Disease-modifying antirheumatic drug (DMARD)
Aminothiol