Medicines
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Discover all available medicines and treatments
Brand: DTIC-Dome
Dacarbazine is an alkylating antineoplastic agent used primarily in the treatment of metastatic malignant melanoma. It belongs to the triazene class of chemotherapy drugs and works by damaging the DNA of cancer cells, preventing them from growing and dividing.
Treatment of metastatic malignant melanoma, Hodgkin's disease, and soft tissue sarcomas.
Outcome:
Increased risk of nausea and vomiting
Mechanism:
Additive gastrointestinal toxicity
Outcome:
Increased risk of bleeding
Mechanism:
Platelet inhibition
Outcome:
Reduced dacarbazine absorption
Mechanism:
Altered drug absorption
Most likely new formulation: Liposomal dacarbazine to improve efficacy and reduce toxicity (Year: 2028, 30% confidence)
Based on historical usage patterns and emerging research, there is a low (5%) likelihood of a significant change in regulatory status in the next 5 years.
Alkylating Agent, Antineoplastic
Triazene