Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Enablex, Emselex
Darifenacin is a muscarinic receptor antagonist, specifically an M3 selective antagonist, used to treat overactive bladder (OAB). It works by blocking the action of acetylcholine at M3 receptors in the bladder, reducing bladder contractions and the urge to urinate.
For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Outcome:
Increased darifenacin levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Increased darifenacin levels
Mechanism:
Inhibition of CYP3A4 metabolism
Outcome:
Additive anticholinergic effects
Mechanism:
Similar mechanism of action
Most likely new formulation: extended-release formulation with improved tolerability (2025, 30% confidence)
Based on current usage trends and clinical trial data, there is a low probability ( <5%) of any major regulatory changes in the next 2 years.
Urinary Antispasmodic, Muscarinic Antagonist
Quinuclidine derivative