Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Prezista
Darunavir is an antiretroviral medication used in combination with other medications to treat human immunodeficiency virus (HIV) infection. It belongs to a class of drugs called protease inhibitors. Darunavir works by blocking the activity of HIV protease, an enzyme essential for viral replication. This prevents the virus from multiplying and can help reduce the amount of HIV in the body.
For the treatment of human immunodeficiency virus (HIV) infection in combination with other antiretroviral agents.
Outcome:
Decreased darunavir levels
Mechanism:
Induction of CYP3A4
Outcome:
Decreased darunavir absorption
Mechanism:
Chelation/altered pH
Outcome:
Potential drug interaction
Mechanism:
Competition for CYP3A4 metabolism
Most likely new formulation: Long-acting injectable formulation (Year 2025, 70% confidence)
Based on current usage trends and clinical trial data, darunavir is expected to maintain its approval status for the treatment of HIV-1 infection.
Antiretroviral, Protease Inhibitor
Bis-tetrahydrofuran