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Brand: Dextran 40, Dextran 70, Gentran, Rheomacrodex, Macrodex
Dextran is a complex branched glucan (polysaccharide made of many glucose molecules) used as an antithrombotic (prevents blood clots), to reduce blood viscosity (thickness), and as a volume expander in hypovolemia (low blood volume). It is available in multiple molecular weights, which influences its effects and duration of action. It is classified as a colloid.
Used to prevent blood clots, reduce blood viscosity, and expand plasma volume.
Outcome:
Increased risk of bleeding
Mechanism:
Both drugs affect blood clotting.
Outcome:
Increased risk of hypotension
Mechanism:
Additive hypotensive effects.
Outcome:
Reduced dextran absorption
Mechanism:
Antacids can alter gastric pH.
Most likely new formulation: Dextran conjugated with targeted drug delivery systems (2026, 65% confidence)
Based on current usage trends and ongoing research, there is a 70% likelihood of expanded indications for dextran in the next 5 years.
Plasma Volume Expander, Antithrombotic
Polysaccharide (Glucan)