Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Diane-35, Dianette, Cilag, Belara
Diane-35 is a combination oral contraceptive pill containing cyproterone acetate, an antiandrogen, and ethinyl estradiol, an estrogen. It is primarily prescribed for the treatment of acne and hirsutism (excessive hair growth) in women, but it also functions as a contraceptive. It works by suppressing androgen production and activity, which helps to reduce the symptoms of these conditions. Diane-35 is generally not recommended as a first-line contraceptive for women solely seeking birth control due to the higher risk of venous thromboembolism (VTE) compared to other combined oral contraceptives containing different progestogens.
For the treatment of acne, hirsutism, and as an oral contraceptive.
Outcome:
Reduced contraceptive efficacy
Mechanism:
Induction of hepatic enzymes
Outcome:
Increased estrogen exposure
Mechanism:
Inhibition of CYP3A4
Outcome:
May increase estrogen levels
Mechanism:
Altered metabolism
Most likely new formulation: Transdermal or lower dose combined pill with improved safety profile (2025+, 30% confidence)
Based on the current regulatory landscape and safety concerns surrounding combined hormonal contraceptives containing cyproterone acetate, there is a low likelihood of FDA approval in the near future.
Hormonal Contraceptive, Antiandrogen
Steroid