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Brand: Ca-DTPA, Zn-DTPA
Diethylenetriaminepentaacetic acid (DTPA) is a chelating agent that binds to metal ions, such as radioactive isotopes of plutonium, americium, and curium, forming stable complexes that are then excreted from the body. It is used to treat internal contamination with these radioactive materials, reducing the radiation dose received by tissues. DTPA belongs to the class of aminopolycarboxylic acids and is available as calcium and zinc salts.
Used to treat internal contamination with radioactive isotopes of plutonium, americium, and curium.
Outcome:
Reduced efficacy of DTPA
Mechanism:
Competition for binding to DTPA
Outcome:
Reduced absorption of DTPA
Mechanism:
Chelation of DTPA by metal ions in antacids
Outcome:
Slightly reduced absorption of DTPA
Mechanism:
Binding of DTPA to food components
Most likely new formulation: Aerosol formulation for pulmonary exposure (Year: 2028, 60% confidence)
Based on current usage and safety profile, DTPA is expected to remain approved for its current indications with >95% likelihood.
Chelating Agent
Aminopolycarboxylic Acid