Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Dramamine, Gravol, Travel-Ease, Triptone, Travtabs
Dimenhydrinate is an over-the-counter antihistamine used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness. It is a combination of diphenhydramine and 8-chlorotheophylline, belonging to the ethanolamine class of antihistamines. The diphenhydramine component acts as an antagonist at H1 histamine receptors, while 8-chlorotheophylline is thought to reduce drowsiness associated with diphenhydramine. Dimenhydrinate is available in various forms, including tablets, chewable tablets, liquid, and suppositories.
For the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness.
Outcome:
Increased drowsiness and impaired coordination
Mechanism:
Additive CNS depression
Outcome:
Increased antihistaminic effects
Mechanism:
Additive effects
Outcome:
May slightly decrease drowsiness
Mechanism:
Caffeine is a CNS stimulant
Most likely new formulation: Extended-release formulation (2025, 70% confidence)
Based on consistent OTC availability and safety profile, dimenhydrinate is predicted to remain readily available with a >95% likelihood over the next 5 years.
Antihistamine, Antiemetic
Ethanolamine