Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Aricept, Donectil, Yasnal
Donepezil is a cholinesterase inhibitor used primarily to treat the symptoms of Alzheimer's disease. It works by increasing the levels of acetylcholine, a neurotransmitter essential for learning and memory, in the brain. Donepezil is classified as a centrally acting reversible acetylcholinesterase inhibitor and belongs to the piperidine class of chemicals. It is often prescribed in the mild to moderate stages of Alzheimer's, and while it doesn't cure the disease, it can help improve or stabilize cognitive function, including memory, attention, and language.
For the symptomatic treatment of mild, moderate, and severe Alzheimer's disease.
Outcome:
Increased donepezil levels, leading to increased side effects.
Mechanism:
Ketoconazole inhibits CYP3A4, which metabolizes donepezil.
Outcome:
Reduced efficacy of donepezil.
Mechanism:
Anticholinergics counteract the cholinergic effects of donepezil.
Outcome:
No clinically significant interaction expected.
Mechanism:
Minimal CYP2D6 inhibition.
Most likely new formulation: Transdermal patch (Year 2025, 70% confidence)
Based on current usage trends and clinical trial data, there is a 90% likelihood that donepezil will remain a first-line treatment for Alzheimer's disease for the next 5 years.
Cholinesterase Inhibitor, Acetylcholinesterase Inhibitor
Piperidine