Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Doribax
Doripenem is a broad-spectrum carbapenem antibiotic used to treat complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis. It is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial cell death. Doripenem is effective against a wide range of gram-positive and gram-negative bacteria, including many resistant strains.
For the treatment of complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis.
Outcome:
Reduced valproic acid levels, increasing the risk of seizures.
Mechanism:
Doripenem may decrease valproic acid concentrations.
Outcome:
Potential cross-reactivity or additive toxicity
Mechanism:
Both are carbapenems with similar mechanisms of action.
Outcome:
No significant interaction expected.
Mechanism:
Cilastatin is often co-administered with imipenem, but not with doripenem.
Most likely new formulation: Extended-release doripenem (Year 2026, 60% confidence)
Based on current usage trends and resistance patterns, there is a 70% likelihood that doripenem will remain a valuable treatment option for complicated infections for the next 5 years.
Carbapenem Antibiotic
Carbapenem