Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Prothiaden, Dosulepin
Dothiepin is a tricyclic antidepressant (TCA) primarily used to treat major depressive disorder. It works by increasing the levels of certain neurotransmitters, such as serotonin and norepinephrine, in the brain. Dothiepin belongs to the class of dibenzoxepines and exhibits sedative properties, which can be helpful for patients with anxiety or insomnia related to their depression. However, it can also cause a range of side effects.
For treating major depressive disorder, sometimes used for insomnia and anxiety associated with depression.
Outcome:
Hypertensive crisis
Mechanism:
Increased serotonin and norepinephrine levels
Outcome:
Increased dothiepin levels
Mechanism:
Inhibition of dothiepin metabolism
Outcome:
Reduced dothiepin absorption
Mechanism:
Binding of dothiepin in the GI tract
Most likely new formulation: Extended-release formulation to improve adherence (Year: 2026, 30% confidence)
Based on historical trends and current research, there is a low probability ( <5%) of FDA approval for dothiepin in the next 5 years.
Tricyclic Antidepressant
Dibenzoxepin