Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Silenor, Sinequan, Zonalon
Doxepin is a tricyclic antidepressant (TCA) primarily used to treat depression and anxiety. It works by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine, which are believed to play a role in mood regulation. Doxepin also has sedative and antihistaminic properties, contributing to its effectiveness in treating insomnia and itching.
For depression, anxiety, insomnia, and itching.
Suicidal thoughts and behavior in children, adolescents, and young adults taking antidepressants.
Outcome:
Serotonin syndrome
Mechanism:
Increased serotonin levels
Outcome:
Increased sedation
Mechanism:
Additive CNS depression
Outcome:
Reduced doxepin efficacy
Mechanism:
Antagonism of doxepin's sedative effects
Most likely new formulation: Extended-release capsules for improved adherence (Year: 2025, 60% confidence)
Based on current usage trends and emerging research, there is a 70% likelihood that doxepin will maintain its current regulatory status for the next 5 years.
Tricyclic Antidepressant
Dibenzoxepin