Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Cymbalta, Yentreve, Xeristar, Ariclaim
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant used to treat major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. It works by increasing the levels of serotonin and norepinephrine, two neurotransmitters in the brain that are believed to play a role in mood regulation and pain signaling.
For major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.
Suicidal thoughts and behavior in children, adolescents, and young adults.
Outcome:
Serotonin syndrome
Mechanism:
Increased serotonin levels
Outcome:
Weakness, hyperreflexia, incoordination
Mechanism:
Serotonin syndrome
Outcome:
Decreased duloxetine absorption
Mechanism:
Chelation
Most likely new formulation: Extended-release formulation for improved patient compliance (2025, 70% confidence)
Based on current usage trends and clinical trial data, there is a low (<5%) likelihood of significant regulatory changes in the next 2 years.
Antidepressant, SNRI
(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine