Medicines
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Discover all available medicines and treatments
Brand: Inspra
Eplerenone is a selective aldosterone blocker used primarily to treat heart failure and high blood pressure. It belongs to the class of mineralocorticoid receptor antagonists (MRAs) and works by blocking the binding of aldosterone, a hormone that plays a role in fluid and electrolyte balance. By inhibiting aldosterone, eplerenone helps reduce sodium and water retention, which can lower blood pressure and improve heart function in patients with heart failure.
For treating heart failure and high blood pressure.
Outcome:
Hyperkalemia
Mechanism:
Additive potassium retention
Outcome:
Increased lithium levels and toxicity
Mechanism:
Reduced lithium excretion
Outcome:
Reduced eplerenone absorption
Mechanism:
Chelation
Most likely new formulation: extended-release formulation (2025, 70% confidence)
Based on current usage trends and clinical trial data, there is a low (5%) likelihood of any major regulatory changes in the next 2 years.
Mineralocorticoid Receptor Antagonist, Potassium-Sparing Diuretic
Steroid lactone