Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Ergotrate Maleate, Methergine
Ergonovine, also known as ergometrine, is a medication primarily used to prevent or control postpartum hemorrhage (excessive bleeding after childbirth). It belongs to the ergot alkaloid class of drugs and works by causing uterine contractions, helping to constrict blood vessels and reduce bleeding. It can also be used to induce or augment labor, though its use for this purpose is less common due to potential side effects.
Used to prevent or control postpartum hemorrhage and occasionally to induce or augment labor.
Outcome:
Increased risk of vasoconstriction, potentially leading to hypertension or stroke.
Mechanism:
Both drugs cause vasoconstriction.
Outcome:
Increased vasoconstriction.
Mechanism:
Additive vasoconstricting effects.
Outcome:
May slightly reduce ergonovine absorption.
Mechanism:
Changes in gastric pH.
Most likely new formulation: sustained-release oral formulation for postpartum hemorrhage prevention (Year: 2026, 60% confidence).
Based on historical usage patterns and current guidelines, there is a low probability of regulatory changes to ergonovine's approved indications within the next 5 years (less than 10% likelihood).
Oxytocic, Ergot Alkaloid
Ergot Alkaloid