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Brand: Edecrin
Ethacrynic acid is a loop diuretic used to treat edema (fluid retention) associated with congestive heart failure, cirrhosis of the liver, kidney disease, and other conditions. It works by inhibiting sodium and chloride reabsorption in the kidneys, leading to increased urine output. It belongs to the phenoxyacetic acid class of diuretics and is considered a "high-ceiling" diuretic due to its potent effect.
For treating edema (fluid retention) associated with heart failure, liver disease, and kidney disease.
Outcome:
Increased risk of ototoxicity (hearing loss)
Mechanism:
Additive effects on inner ear function
Outcome:
Additive hypotensive effect
Mechanism:
Synergistic effects on blood pressure
Outcome:
Decreased absorption of ethacrynic acid
Mechanism:
Altered gastric pH
Most likely new formulation: sustained-release formulation (Year: 2026, 30% confidence)
Based on current usage trends and safety profile, there is a low probability ( <5%) of regulatory changes in the next 5 years.
Loop Diuretic
Phenoxyacetic acid derivative