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Discover all available medicines and treatments
Brand: Trecator, Trescatyl
Ethionamide is an antibiotic used in the treatment of tuberculosis (TB). It belongs to the thioamide class of antimycobacterial agents and works by inhibiting the synthesis of mycolic acids, essential components of the mycobacterial cell wall. It's typically used in combination with other anti-TB drugs, especially for multidrug-resistant TB (MDR-TB) or when other first-line drugs are ineffective.
For the treatment of drug-resistant tuberculosis, often in combination with other anti-TB medications.
Outcome:
Increased risk of hepatotoxicity
Mechanism:
Additive liver toxicity
Outcome:
Reduced absorption of ethionamide
Mechanism:
Chelation
Outcome:
May reduce gastrointestinal side effects
Mechanism:
Delayed absorption
Most likely new formulation: Extended-release formulation to improve patient adherence (Year: 2026, 70% confidence).
Based on increasing resistance patterns to first-line TB drugs, the likelihood of ethionamide's continued use in MDR-TB treatment remains high (85% confidence).
Antimycobacterial, Thioamide
Thioamide