Medicines
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Discover all available medicines and treatments
Brand: VePesid, Etopophos, Toposar
Etoposide is a semisynthetic derivative of podophyllotoxin, a plant-derived compound. It is classified as a topoisomerase II inhibitor, meaning it interferes with the action of an enzyme crucial for DNA replication and repair in cancer cells. This leads to DNA strand breaks and ultimately cell death. Etoposide is used in a variety of cancers, often in combination with other chemotherapeutic agents.
Etoposide is used to treat various cancers, including testicular cancer, lung cancer, lymphomas, leukemias, and other solid tumors.
Myelosuppression (low blood counts), including potentially fatal infections and bleeding; secondary malignancies, including acute myeloid leukemia; infusion-related hypotension and anaphylaxis; tumor lysis syndrome; embryo-fetal toxicity.
Outcome:
Increased bleeding risk
Mechanism:
Altered metabolism
Outcome:
Reduced etoposide absorption
Mechanism:
Chelation
Outcome:
Increased bleeding risk
Mechanism:
Additive platelet inhibition
Most likely new formulation: Liposomal etoposide for improved delivery and reduced toxicity (2025, 30% confidence)
Based on historical data and current clinical trials, there is a low probability of a major label change for etoposide in the next 2 years (<5%).
Antineoplastic, Topoisomerase II Inhibitor
Podophyllotoxin Derivative