Medicines
Discover all available medicines and treatments
Discover all available medicines and treatments
Brand: Zetia, Ezetrol
Ezetimibe is a lipid-lowering medication that selectively inhibits the intestinal absorption of cholesterol and related plant sterols. It belongs to the class of drugs known as cholesterol absorption inhibitors. Ezetimibe works by targeting a specific protein involved in cholesterol transport, NPC1L1, reducing the amount of cholesterol entering the bloodstream from the diet and bile. This mechanism complements the action of statins, which reduce cholesterol production in the liver.
Used to lower cholesterol levels in the blood and reduce the risk of cardiovascular events.
Outcome:
Increased ezetimibe levels
Mechanism:
Inhibition of metabolism
Outcome:
Slightly decreased ezetimibe absorption
Mechanism:
Altered pH
Outcome:
Generally safe to use together
Mechanism:
No known significant interaction
Most likely new formulation: Combination therapy with other lipid-lowering agents (2024, 70% confidence)
Based on current usage trends and clinical trial data, there is a low probability (<5%) of any major regulatory changes for ezetimibe in the next 2 years.
Cholesterol Absorption Inhibitor
2-Azetidinone